ArginoCarn® & Neurological Health

ArginoCarn® supports both healthy brain function and neurological health. This is accomplished by stimulating the release of acetylcholine and dopamine, two neurotransmitters vital for neurological health and cognition.

Neurological Health & Acetyl-L-Carnitine

Recent studies of ArginoCarn® as an Acetyl-L-Carnitine Arginate prove to have benefits beyond neurological health. It has also been shown to be responsible for maintaining calcium homeostasis in nervous system cells stimulated by glutamate, which promotes healthy neurite function. Neurites are hair-like cellular projections which are responsible for proper signal transmission in the nervous system.

Benefits Beyond Neurological Health

In addition to supporting neurological health, ArginoCarn® is also responsible for assisting in the production of acetylcholine. Acetylcholine is an essential nutrient necessary for healthy nervous system functions. Results from a recent double blind clinical study have shown ArginoCarn® plays a positive role in promoting healthy cognitive function, and demonstrates its ability to inhibit negative cognitive changes. ArginoCarn® has been shown to statistically improve mental attention and memory.

Dietary Benefits

Edwards, R. L., K. Moseley, et al. (2009). "Long-Term Neurodevelopmental Effects of Early Detection and Treatment in a 6-Year-Old Patient with Argininaemia Diagnosed by Newborn Screening." J Inherit Metab Dis.

Newborn screening makes possible the early identification and treatment of asymptomatic ARG1-deficient patients; however, it is unknown whether early intervention prevents neurological insults. We identified a full-term Hispanic male infant with argininaemia by newborn screening with a serum arginine of 327 micromol/L (reference values 0-140); ARG1 was undetectable on enzyme assay. Sequence analysis of ARG1 revealed a heterozygous nonsense mutation, c.223A>T (p.K75X), and a novel...

Scorziello, A., O. Meucci, et al. (1997). "Acetyl-L-Carnitine Arginine Amide Prevents Beta 25-35-Induced Neurotoxicity in Cerebellar Granule Cells." Neurochem Res 22(3): 257-265.

Cerebellar granule cells (CGC) at different stages of maturation in vitro (1 or 6 DIV), were treated with beta 25-35 and acetyl-L-carnitine arginine amide (ST857) in presence of 25 mM KCl in the culture medium, and neuronal viability was assessed. Three days of treatment slightly modified the survival of 1 DIV-treated cells, which degenerate and die five days later beta-amyloid matching. Similarly, a significative neurotoxic effect was observed on 6 DIV treated-cells after 5 days of exposure to the peptide, while the death...

Taglialatela, G., D. Navarra, et al. (1995). "Neurite Outgrowth in Pc12 Cells Stimulated by Acetyl-L-Carnitine Arginine Amide." Neurochem Res 20(1): 1-9.

Senescence of the central nervous system is characterized by a progressive loss of neurons that can result in physiological and behavioral impairments. Reduction in the levels of central neurotrophic factors or of neurotrophin receptors may be one of the causes of the onset of these degenerative events. Thus, a proper therapeutic approach would be to increase support to degenerating neurons with trophic factors or to stimulate endogenous neurotrophic activity. Here we report that acetyl-L-carnitine arginine...

Tewari, K., J. M. Simard, et al. (1995). "Acetyl-L-Carnitine Arginyl Amide (St857) Increases Calcium Channel Density in Rat Pheochromocytoma (Pc12) Cells." J Neurosci Res 40(3): 371-378.

We used the patch clamp technique to study the effect of acetyl-L-carnitine arginyl amide (ALCAA) and of nerve growth factor (NGF) on availability of L-type Ca2+ channels in rat pheochromocytoma (PC12) cells maintained in defined medium. Channel availability was measured as number of channels in the patch x the probability of opening (n.Po). In patches from control cells, cells exposed to NGF (10 ng/ml) for six days, and cells exposed to ALCAA (1 mM) for six days, n.Po, measured during 200-240 ms pulses to -10 mV...

Westlund, K. N., Y. Lu, et al. (1992). "Effects of Nerve Growth Factor and Acetyl-L-Carnitine Arginyl Amide on the Human Neuronal Line Hcn-1a." Int J Dev Neurosci 10(5): 361-373.

The HCN-1A clonal cell line, derived from the cortical tissue of a patient with unilateral megencephaly, was shown to differentiate into a mature neuronal-like state in the presence of the nerve growth factor, dibutyryl cyclic adenosine, 3',5'-monophosphate and either 1-isobutyl-3-methylxanthine or forskolin. Differentiation was assessed by measuring the percentage of cells that displayed branched, varicose processes that stained for synaptophysin. Treatment of cultures with a cocktail containing forskolin...

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